Impaired splenic function in systemic amyloidosis.

Impaired splenic function in systemic amyloidosis.

In four cases of biopsy proven amyloidosis there was evidence of impaired splenic function. All had absent or grossly reduced splenic uptake on colloid isotope scans and three had haematological changes consistent with hyposplenism. Poor splenic function with a normal sized or enlarged spleen may be a clue to underlying amyloid.

Consequences of impaired splenic function.

Development of impaired splenic function in intestinal lymphangiectasia.

We describe a patient with intestinal lymphangiectasia who developed hyposplenism and speculate that it resulted from chronic loss of lymphocytes into the gut.

Amyloidosis - Pathogenesis | Systemic amyloidosis | Pharmacybook

Amyloidosis - Pathogenesis | Systemic amyloidosis | Pharmacybook